Controversies concerning mitochondrial replacement therapy

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Estrogen replacement therapy and cardioprotection: mechanisms and controversies.

Epidemiological and case-controlled studies suggest that estrogen replacement therapy might be beneficial in terms of primary prevention of coronary heart disease (CHD). This beneficial effect of estrogens was initially considered to be due to the reduction of low density lipoproteins (LDL) and to increases in high density lipoproteins (HDL). Recent studies have shown that estrogens protect aga...

متن کامل

Mito-nuclear Incompatibilities and Mitochondrial Replacement Therapy

Mitochondrial replacement therapy (MRT) is a human reproductive technology by which the mitochondria of a recipient’s eggs are effectively replaced by those of a donor, potentially eliminating harmful mitochondrial mutations carried by the recipient. However, concerns have been raised that MRT may lead to problems due to incompatibilities between the nuclear genome of the recipient and mitochon...

متن کامل

Controversies concerning vitamin K and the newborn.

Prevention of early vitamin K deficiency bleeding (VKDB) of the newborn, with onset at birth to 2 weeks of age (formerly known as classic hemorrhagic disease of the newborn), by oral or parenteral administration of vitamin K is accepted practice. In contrast, late VKDB, with onset from 2 to 12 weeks of age, is most effectively prevented by parenteral administration of vitamin K. Earlier concern...

متن کامل

Present problems and controversies concerning pregnant adolescents

Faustino R Pérez-López1 Peter Chedraui2,4 Amy S Kravitz3 Danny Salazar-Pousada2 Luis Hidalgo4 1Department of Obstetrics and Gynaecology, Facultad de Medicina, Universidad de Zaragoza, Hospital Clínico, Zaragoza, Spain; 2High Risk Pregnancy Labor and Delivery Unit, Hospital Gineco-Obstétrico enrique C. Sotomayor, Guayaquil, ecuador; 3Jay weiss Center of Social Medicine and Global Health equity, ...

متن کامل

Mitochondrial replacement therapy: Cautiously replace the master manipulator.

Around 1 in 200 children born each year have mutations in the mitochondrial DNA (mtDNA)—the genome of the cellular powerhouse. In most cases this causes only mild disease, often without any symptoms. However, for about 1 in 6,500 individuals, mitochondrial disease causes serious and often fatal conditions, which include blindness, muscular weakness, and heart failure. Currently available therap...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Fertility and Sterility

سال: 2015

ISSN: 0015-0282

DOI: 10.1016/j.fertnstert.2014.10.028